Revisiting the relationship between complement and ulcerative colitis

Abstract Ulcerative colitis (UC) is an inflammatory bowel disorder (IBD) characterized by relapsing chronic inflammation of the colon that causes continuous mucosal inflammation. The global incidence UC steadily increasing. Immune mechanisms are involved in pathogenesis UC, which complement shown to play a critical role inducing local responses promote tissue damage. However, function various components development complex and even paradoxical. Some (e.g. C1q, CD46, CD55, CD59, C6) safeguard intestinal barrier reduce inflammation, while others C3, C5, C5a) can exacerbate damage accelerate UC. system was originally thought primarily extracellular mode; however, recent evidence indicates it also act intracellularly as complosome. current study provides overview studies on its While there few describe how intracellular contributes we discuss potential future directions based related publications. We highlight novel methods target for IBD treatment.